U.S. Vice President Joe Biden, right, and Republican vice presidential candidate Paul Ryan depart the stage following their debate on Thursday, October 11. 
President Barack Obama watches the vice presidential debate aboard Air Force One with staff while heading home from Florida on Thursday. 
Vice President Joe Biden and U.S. Rep. Paul Ryan walk off stage after the vice presidential debate. 
Vice presidential candidate Ryan greets family following his debate with Vice President Biden. 
Vice President Joe Biden and Rep. Paul Ryan mingle with their families after the debate. 
Vice President Biden smiles during the debate. 
Rep. Paul Ryan listens closely during the debate. 
Vice President Biden and vice presidential candidate U.S. Rep. Ryan go head to head in the first and only vice presidential debate. 
Vice President Biden reacts to comments made during the debate. 
Vice presidential candidate Ryan lays out his views. 
Vice President Biden responds to points made. 
Vice presidential candidate Paul Ryan engages the moderator during the vice presidential debate. 
U.S. Vice President Joe Biden, left, engages in the first and only vice presidential debate on Thursday, October 11. 
Vice President Biden reacts during the debate. 
Vice President Biden and vice presidential candidate Paul Ryan face off. 
Vice President Biden greets Republican vice presidential candidate Paul Ryan as they take the stage. 
Vice President Joe Biden speaks during the vice presidential debate as moderator Martha Raddatz looks on. 
Vice President Biden, left, and Republican vice presidential candidate Ryan, right, participate in the debate. 
Ryan speaks during the debate. 
Biden presents his views on Thursday. 
Ryan awaits his turn to speak. 
Vice President Joe Biden, left, shakes hands with Republican vice presidential candidate Paul Ryan before the vice presidential debate. 
Janna Ryan, wife of Paul Ryan, waves to the crowd. 
Dr. Jill Biden, wife of Joe Biden, greets the crowd. 
An audience member holds a debate program. 
Debate moderator Martha Raddatz speaks to the crowd prior to the start of the vice presidential Debate. 
- The Twittersphere weighs in on Thursday's vice-presidential debate
- Jokes referenced Vice President Joe Biden's laughing and constant interruptions
- People also commented on challenger Paul Ryan's frequent sips of water
- The one and only vice-presidential debate was held in Danville, Kentucky
(CNN) -- When he wasn't laughing, Joe Biden sounded a like a belligerent old man.
Paul Ryan sipped from a cup and looked like a beleaguered altar boy.
Fair or not, those were just two characterizations of Thursday's vice presidential debate on Twitter, where a Greek chorus of jokesters kept up a witty commentary throughout the 90-minute event. As with any live TV event in the social media age, the people of Twitter let no gaffe or verbal tic go unnoticed.
Here are 25 of our favorites:
GuyEndoreKaiser -- Tonight's debate is scheduled for ninety minutes, but Paul Ryan is already claiming he can finish in fifty something.
Best zingers from VP debate Hello 9 1 1? There s an old man beating a child on my tv
â€" Bill Maher (@billmaher) October 12, 2012
Ana Marie Cox -- I actually happen to have "malarkey" in the drinking game! Oh geez...
Jill Morris â€â€ª-- The VP candidates get to sit because they're exhausted from standing up for our values. ‪#VPDebate
Morgan Murphy â€â€ª-- Biden's teeth are so white they're voting for Romney. ‪#VPDebate
The 25 funniest tweets about the first presidential debate
Indecision â€â€ª-- Watered-down sanctions are the worst. You need four just to get tipsy. ‪#vpdebate
Patton Oswalt -- Ryan is a nervous Walmart manager. Biden is an irate customer with the receipt, the warranty & he's friends w/ the store owner. #debate
While Ryan speaks, Biden looks like he's trying to order a drink at the bar and the bartender is ignoring him. #vpdebate
â€" kelly oxford (@kellyoxford) October 12, 2012
Indecision â€â€ª-- Joe Biden would very much like for Paul Ryan to get off his lawn. ‪#vpdebate
Laughing Joe Biden â€â€ª-- Looooooool
Paul and Storm â€â€ª-- You can't make Joe Biden look bad. He is your favorite uncle. He pulls quarters from behind your ears. ‪#VPDebate
Seth Masket â€â€ª-- Actually, this is like if Aaron Sorkin wrote an exchange between the Skipper and Gilligan. ‪#vpdebate
Leah â€â€ª-- JOE. SHUT THE HECK UP AND WAIT YOUR TURN. ‪#VPdebate
Whoever is tickling Biden's feet needs to stop it. #VPDebate
â€" Joe Mande (@JoeMande) October 12, 2012
Sean Becker -- "Oh, I get it now." - Jim Lehrer
Paul Ryan Gosling â€â€ª-- Hey girl, I'm not taking nervous sips of water, I'm drinking every time Biden laughs at me. ‪#vpdebate
Jose Antonio Vargas â€â€ª-- Before this ‪#VPDebate, ‪@JoeBiden had a Venti macchiato and two cans of Red Bull.
James Garrett â€â€ª-- I kind of feel like Joe Biden is Kanye and Paul Ryan is Taylor Swift. ‪#VPDebate
This is like Alex and Mr. Keaton in season 30 of Family Ties #VPDebate
â€" Peter Schultz (@pete_schultz) October 12, 2012
National Review â€â€ª-- Wait, is Biden yelling at Martha Raddatz right now? I thought he was debating Paul Ryan...‪#VPDebate
Brent Black â€â€ª-- I HAVE HAD A CHILD IN THE SHAPE OF A BEAN PLEASE INTERRUPT ME ‪#VPDebate
Laughing Joe Biden â€â€ª-- teeheehehe
The good news is Bill and Ted may ride again. The bad news is i've been replaced. twitter.com/alxwinter/stat...
â€" Alex Winter (@alxwinter) October 11, 2012
Jeffrey Wisenbaugh â€â€ª-- Biden is yelling less. I think it's getting closer to his bed time. ‪#sleepy ‪#VPDebate
Chad Schomber â€â€ª-- To think, all this just to sway 4-6% of undecided voters. And those folks are not watching the ‪#VPdebate
CNN's Doug Gross and John D. Sutter contributed to this story.
