- Republicans want Newt Gingrich and Ron Paul to drop out, a new poll says
- Poll: Gingrich supporters tend to back Mitt Romney as their second choice
- Romney holds a 2-to-1 lead over Rick Santorum in the delegate count
- Gingrich, Paul and Santorum say they will stay in the race
Washington (CNN) -- While none of the Republican candidates have heeded the increasing calls for them to drop out and cede the race to front-runner Mitt Romney, news broke late Tuesday that Newt Gingrich has replaced his campaign manager and is laying off one-third of his staff.
Even with the reorganization, the former speaker of the House has vowed to continue his bid for the presidential nomination.
The overhaul comes as a CNN/ORC International poll released Tuesday indicated that most Republicans would like to see Gingrich and Texas Rep. Ron Paul end their White House bids.
But, at the same time, they also want conservative challenger Rick Santorum to stay in the race.
Did Romney mishandle the open mic? 
Gingrich: 'Romney weakest front-runner' 
Santorum bashes Obama over whispering The poll, conducted over the weekend, showed that about six in 10 Republicans want Gingrich and Paul to halt their campaigns, while a similar number supported Santorum continuing his bid.
According to CNN's latest estimate, Romney has secured 569 delegates and needs 575 more to reach the 1,144 required to clinch the GOP nomination.
Santorum, the former Pennsylvania senator, has 262 delegates, with Gingrich at 136 and Paul at 71.
Romney took his campaign to the late-night airwaves Tuesday, making an appearance on the "Tonight Show" with host Jay Leno.
After cracking a few jokes, Romeny and the talk show host settled into a discussion on health care. Many conservatives are uncomfortable with a health care reform package signed by Romney when he was governor of Massachusetts. The Obama administration later modeled -- in part -- its health care reform law on the Massachusetts plan.
Despite the poll showing long odds, none of the three trailing candidates appears close to giving up.
Santorum challenged the delegate math, telling CNN's Wolf Blitzer on Monday that the Republican race was likely to continue until the party's national convention in August in Florida.
"There may be someone with what they say are enough delegates, but as you also know, Wolf, a huge number of delegates are uncommitted," Santorum said. "They may be for me, or they may be for Mitt, but they're technically uncommitted, and therefore you can't put them in your column."
Gingrich said Tuesday that he would drop out if Romney reaches the 1,144-delegate threshold to claim the nomination. However, Gingrich added he doubted that would happen before the convention.
Santorum explains bulls*#* remark 
Romney: Alarmed by Obama open mic gaffe 
Ron Paul: Too soon to write people off "Gov. Romney is the front-runner but is a long way from a majority," Gingrich said at Maryland's capitol building in Annapolis. "If (Romney) does get, by the time Utah votes on the 26th of June, if he gets a majority, obviously I will support him and will be delighted to do anything I can to help defeat Barack Obama."
Paul also sounded committed to staying in the race, telling CNN's "Piers Morgan Tonight" on Monday that "it's way too soon for you to write anybody off."
"Why should we just throw in the towel because people like you say, 'Hey, throw in the towel'? " Paul asked.
According to the new poll, 36% of Republicans support Romney for the nomination, and 26% back Santorum. It was a different story in February, when the two men were effectively tied in CNN's last national survey, with Santorum at 34% and Romney at 32%.
The survey seemed to dispel the commonly-held notion that Gingrich and Santorum were vying for conservative support against the more moderate Romney. According to the poll, most of Gingrich's supporters said Romney was their second choice, rather than Santorum.
"If you recalculate the GOP horse race using the Gingrich voters' second choice, Romney's lead over Santorum grows to 15 percentage points -- 45% for Romney and 30% for Santorum -- compared to the 10-point margin Romney currently has in the four-man field," CNN Polling Director Keating Holland said.
The primary calendar resumes April 3 with contests in Wisconsin, Maryland and the District of Columbia. A three-week break follows until April 24, when New York, Pennsylvania, Delaware, Connecticut and Rhode Island vote.
Those contests in more moderate states in the Northeast, Mid Atlantic and Midwest appear to favor Romney over Santorum, with the possible exception of Pennsylvania, which Santorum represented in Congress for nearly two decades.
CNN's Paul Steinhauser, Tom Cohen and Mark Preston contributed to this report.
